MEMSEAL is a go ! DARPA systems vaccinology initiative.
January 5, 2023 by Blogs Lab | No Comments
The Defense Advanced Research projects Agency (DARPA) selected us as one of the teams leading an ambitious effort to predict the formation of long term immunological memory soon after a vaccination, under the auspices of the Assessing Immune Memory (AIM) program.
Our proposal is a collaboration between three different institutions – the UMSOM, the Computational Biology Section of the National Instutes of Allergy and Infectious Diseases at NIH and Arizona State University Biodesign Institute.
The Collaborating team includes synergistic expertise in clinical, basic and computational immunology :
- The Nevil lab (us :-))
- Martin Meier-Schellersheim – at the Computational Biology Section of the NIAID, NIH
- Vel Murugan – at the Biodesign Insitute, Arizona State University
- Marcella Pasetti – at the Dept of Pediatrics and Center for Vaccine Development at the UMSOM
- Wilbur Chen – – at the Dept of Medicine and Center for Vaccine Development at the UMSOM and a member of the CDC ACIP
Measures for Establishment of Memory Signatures in Early Activated Lymphocytes (MEMSEAL) concept examines multiple human vaccines using a broad array of in vivo measures (including CITEseq, ASAPseq, metabolomics, spectral flow, multiplex cytokines etc) and develops advanced computational pipelines to identify distinct combinatorial signatures capable of foreshadowing the formation of immunological memory.
PS. We have postdoctoral positions open for this project; please contact us if interested.